Go by the expiration date printed on the package. For most OTC medicines, opening the container doesn't start a shorter countdown — storage is what actually shortens a medicine's life.
No countdown to draw — Ibuprofen tablets (Advil, Motrin) goes by the date on the package, not by when you opened it.
Air and warmth are what shorten an opened item's life — the right container buys back the days the packaging gives up once the seal's broken.
Keep Ibuprofen tablets (Advil, Motrin) fresh longer ↗ Need a fresh one? ↗
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Yes — Ibuprofen tablets (Advil, Motrin) carries a printed expiration date and that's the date to go by. Use by the printed expiration date, stored at room temperature and away from moisture. Liquid gel capsules are more sensitive to heat than plain tablets — if they've gone soft or leaky, replace them. Not medical advice — follow the label and ask a pharmacist.
Room temperature 68–77°F (20–25°C), dry, tightly closed in the original bottle. Heat and humidity shorten a medicine's real life faster than the printed date suggests, which is why a bathroom cabinet is the worst place for it. Check the printed date and ask a pharmacist.
Throw it out if you notice: Softened, sticky, or stuck-together tablets; Discoloration; An off or chemical smell; Past the printed expiration date. Not medical advice — ask a pharmacist if you're unsure.